Article
Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Oct 2010
Metzler Martina, Gan Lu, Mazarei Gelareh, Graham Rona K, Liu Lili, Bissada Nagat, Lu Ge, Leavitt Blair R, Hayden Michael R
Abstract excerpt
YAC transgenic mice expressing poly(Q)-expanded full-length huntingtin (mhtt) recapitulate many behavioral and neuropathological features of Huntington disease (HD). We have previously observed a reduction in phosphorylation of mhtt at S421 in the presence of the mutation for HD. In addition, pho...
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