Article

PINK1 regulates cholesterol homeostasis via SCAP phosphorylation in human dopaminergic neurons

2025-08-28

Abstract excerpt

Cholesterol is a key lipid enriched in neuronal membranes and essential for signaling and synaptic transmission. An imbalance in cholesterol levels may affect synaptic plasticity and contribute to neurodegeneration. Here, we identify in human dopaminergic neurons a mechanism linking loss of function of the Parkinson’s disease (PD) gene PINK1 to altered cholesterol homeostasis. Loss of functional PINK1 impaired SC...

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Literature Corpus work: 2a992431-faac-5268-a1f1-5df942bc7ac7
DOI: 10.1101/2025.08.27.672574

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