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Article

An Essential Physiological Role for MCT8 in Bone in Male Mice.

Endocrinology - 1 Sept 2017

Leitch Victoria D, Di Cosmo Caterina, Liao Xiao-Hui, O'Boy Sam, Galliford Thomas M, Evans Holly, Croucher Peter I, Boyde Alan, Dumitrescu Alexandra, Weiss Roy E, Refetoff Samuel, Williams Graham R, Bassett J H Duncan

Abstract excerpt

T3 is an important regulator of skeletal development and adult bone maintenance. Thyroid hormone action requires efficient transport of T4 and T3 into target cells. We hypothesized that monocarboxylate transporter (MCT) 8, encoded by Mct8 on the X-chromosome, is an essential thyroid hormone transporter in bone. To test this hypothesis, we determined the juvenile and adult skeletal phenotypes of male Mct8 knockout...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28637283
DOI: 10.1210/en.2017-00399
PMCID: PMC5659673

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