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Article

MCT8 Deficiency in Male Mice Mitigates the Phenotypic Abnormalities Associated With the Absence of a Functional Type 3 Deiodinase.

Endocrinology - 1 Aug 2016

Stohn J Patrizia, Martinez M Elena, Matoin Kassey, Morte Beatriz, Bernal Juan, Galton Valerie Anne, St Germain Donald, Hernandez Arturo

Abstract excerpt

Mice deficient in the type 3 deiodinase (D3KO mice) manifest impaired clearance of thyroid hormone (TH), leading to elevated levels of TH action during development. This alteration causes reduced neonatal viability, growth retardation, and central hypothyroidism. Here we examined how these phenotypes are affected by a deficiency in the monocarboxylate transporter 8 (MCT8), which is a major contributor to the...

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Identifiers

PMID: 27254003
DOI: 10.1210/en.2016-1162
PMCID: PMC4967121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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