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Article

Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy.

European journal of endocrinology - 1 Oct 2011

Wirth Eva K, Sheu Sien-Yi, Chiu-Ugalde Jazmin, Sapin Remy, Klein Marc O, Mossbrugger Ilona, Quintanilla-Martinez Leticia, de Angelis Martin Hrabĕ, Krude Heiko, Riebel Thomas, Rothe Karin, Köhrle Josef, Schmid Kurt W, Schweizer Ulrich, Grüters Annette

Abstract excerpt

CONTEXT: Thyroid hormone transport across the plasma membrane depends on transmembrane transport proteins, including monocarboxylate transporter 8 (MCT8). Mutations in MCT8 (or SLC16A2) lead to a severe form of X-linked psychomotor retardation, which is characterised by elevated plasma triiodothyronine (T(3)) and low/normal thyroxine (T(4)). MCT8 contributes to hormone release from the thyroid gland. OBJECTIVE:...

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PMID: 21813593
DOI: 10.1530/EJE-11-0369

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