Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Thyrotoxic Skeletal Phenotype of Advanced Bone Formation in Mice with Resistance to Thyroid Hormone

8 Apr 2003

Abstract excerpt

Thyroid hormone (T3) regulates bone turnover and mineralization in adults and is essential for skeletal development during childhood. Hyperthyroidism is an established risk factor for osteoporosis. Nevertheless, T3 actions in bone remain poorly understood. Patients with resistance to thyroid hormone, due to mutations of the T3-receptor beta (TRbeta) gene, display variable phenotypic abnormalities, particularly in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Growth Hormone and Insulin-like Growth Factors
Share to Bone health and treatments
Share to Thyroid Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12677005
DOI: 10.1210/me.2002-0296

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Thyrotoxic Skeletal Phenotype of Advanced Bone Formation in Mice with Resistance to Thyroid HormonePMID 12677005Read ↗

Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta.Semantic proximity Read ↗

Advanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling.Semantic proximity Read ↗

The skeletal phenotypes of TRalpha and TRbeta mutant mice.Semantic proximity Read ↗

Characterization of skeletal phenotypes of TRα1<sup>PV</sup> and TRβ<sup>PV</sup> mutant mice: implications for tissue thyroid status and T3 target gene expressionSemantic proximity Read ↗

Skeletal abnormalities in mice with Dnmt3a missense mutations.Semantic proximity Read ↗

Thyroid diseases and bone health.Semantic proximity Read ↗

Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.Semantic proximity Read ↗

Altered Craniofacial and Bone Morphology in Hyperthyroid Knock-In Mice Carrying TSHR D633H and M453T Mutations.Semantic proximity Read ↗

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts.Semantic proximity Read ↗

Hyperthyroid-associated osteoporosis is exacerbated by the loss of TSH signaling.Semantic proximity Read ↗

Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fracturesSemantic proximity Read ↗

Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.