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Monocarboxylate Transporter 10 Functions as a Thyroid Hormone Transporter in Chondrocytes

19 Jun 2012

Abstract excerpt

Thyroid hormone is essential for normal proliferation and differentiation of chondrocytes. Thus, untreated congenital hypothyroidism is marked by severe short stature. The monocarboxylate transporter 8 (MCT8) is a highly specific transporter for thyroid hormone. The hallmarks of Allan-Herndon-Dudley syndrome, caused by MCT8 mutations, are severe psychomotor retardation and elevated T(3) levels. However, growth is...

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PMID: 22719050
DOI: 10.1210/en.2011-1713

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