Article

Deletion of <i>Dock7</i> Exons 3 and 4 Results in Reduced Trabecular Bone Microarchitecture

2026-01-02

Abstract excerpt

Dedicator of Cytokinesis 7 (DOCK7) has recently emerged as a regulator of skeletal homeostasis, but existing Dock7 mutant models harbor only global mutations and are incompatible with tissue-specific deletion studies. We previously generated a Dock7 -floxed allele in which exons 3–4 are flanked by LoxP sites. To validate the utility of this allele for future conditional strategies, we globally deleted exons 3–4...

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Literature Corpus work: 465eb3a7-cc02-544b-bbb9-90402a84cd6d
DOI: 10.64898/2025.12.31.696872

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