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Article

Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptor

15 Jul 2008

Abstract excerpt

UL18 is a human cytomegalovirus class I MHC (MHCI) homolog that binds the host inhibitory receptor LIR-1 and the only known viral MHC homolog that presents peptides. The 2.2-A structure of a LIR-1/UL18/peptide complex reveals increased contacts and optimal surface complementarity in the LIR-1/UL18 interface compared with LIR/MHCI interfaces, resulting in a >1,000-fold higher affinity. Despite sharing only...

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PMID: 18632577
DOI: 10.1073/pnas.0804551105

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Structure of UL18, a peptide-binding viral MHC mimic, bound to a host inhibitory receptorPMID 18632577Read ↗

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