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Article

Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove

29 Jan 2016

Abstract excerpt

HLA class I presentation of pathogen-derived peptide ligands is essential for CD8+ T-cell recognition of Toxoplasma gondii infected cells. Currently, little data exist pertaining to peptides that are presented after T. gondii infection. Herein we purify HLA-A*02:01 complexes from T. gondii infected cells and characterize the peptide ligands using LCMS. We identify 195 T. gondii encoded ligands originating from...

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PMID: 26824387
DOI: 10.7554/elife.12556

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