Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues.

doi:10.1136/gutjnl-2016-313146

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Article

Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues.

Gut - 1 Mar 2018

Zhang Mingfeng, Lykke-Andersen Soren, Zhu Bin, Xiao Wenming, Hoskins Jason W, Zhang Xijun, Rost Lauren M, Collins Irene, Bunt Martijn van de, Jia Jinping, Parikh Hemang, Zhang Tongwu, Song Lei, Jermusyk Ashley, Chung Charles C, Zhu Bin, Zhou Weiyin, Matters Gail L, Kurtz Robert C, Yeager Meredith, Jensen Torben Heick, Brown Kevin M, Ongen Halit, Bamlet William R, Murray Bradley A, McCarthy Mark I, Chanock Stephen J, Chatterjee Nilanjan, Wolpin Brian M, Smith Jill P, Olson Sara H, Petersen Gloria M, Shi Jianxin, Amundadottir Laufey

Abstract excerpt

OBJECTIVE: To elucidate the genetic architecture of gene expression in pancreatic tissues. DESIGN: We performed expression quantitative trait locus (eQTL) analysis in histologically normal pancreatic tissue samples (n=95) using RNA sequencing and the corresponding 1000 genomes imputed germline genotypes. Data from pancreatic tumour-derived tissue samples (n=115) from The Cancer Genome Atlas were included for...

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PMID: 28634199
DOI: 10.1136/gutjnl-2016-313146
PMCID: PMC5762429

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