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Splicing transcriptome-wide association study to identify splicing events for pancreatic cancer risk.

Carcinogenesis - 15 Dec 2023

Liu Duo, Bae Ye Eun, Zhu Jingjing, Zhang Zichen, Sun Yanfa, Deng Youping, Wu Chong, Wu Lang

Abstract excerpt

A large proportion of the heritability of pancreatic cancer risk remains elusive, and the contribution of specific mRNA splicing events to pancreatic cancer susceptibility has not been systematically evaluated. In this study, we performed a large splicing transcriptome-wide association study (spTWAS) using three modeling strategies (Enet, LASSO and MCP) to develop alternative splicing genetic prediction models...

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PMID: 37769343
DOI: 10.1093/carcin/bgad069

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