Article
Aberrant RNA Splicing Is a Primary Link between Genetic Variation and Pancreatic Cancer Risk.
Cancer research - 6 Jun 2022
Tian Jianbo, Chen Can, Rao Meilin, Zhang Ming, Lu Zequn, Cai Yimin, Ying Pingting, Li Bin, Wang Haoxue, Wang Lu, Li Yao, Huang Jinyu, Fan Linyun, Cai Xiaomin, Ning Caibo, Li Yanmin, Zhang Fuwei, Wang Wenzhuo, Jiang Yuan, Liu Yizhuo, Wang Min, Li Heng, Huang Chaoqun, Yang Zhiyong, Chang Jiang, Zhu Ying, Yang Xiaojun, Miao Xiaoping
Abstract excerpt
Understanding the genetic variation underlying transcript splicing is essential for fully dissecting the molecular mechanisms of common diseases. The available evidence from splicing quantitative trait locus (sQTL) studies using pancreatic ductal adenocarcinoma (PDAC) tissues have been limited to small sample sizes. Here we present a genome-wide sQTL analysis to identify SNP that control mRNA splicing in 176 PDAC...
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