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Transposon insertion sequencing of <i>Pseudomonas aeruginosa</i> identifies multiple intersecting pathways essential for extreme colistin resistance

2026-04-16

Abstract excerpt

Colistin is used to treat antibiotic resistant gram-negative infections, including those caused by Pseudomonas aeruginosa ( Pa ). Using a diverse collection of clinical isolates, we identified BWH047, a colistin-resistant isolate with an extremely high minimum inhibitory concentration (MIC, 1280 µg/mL). To characterize the genes conditionally essential for colistin resistance in BWH047, we employed transposon in...

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Literature Corpus work
d8631aaf-bcaa-5638-8515-215eccf1240b
DOI
10.64898/2026.04.13.718186
Open publication

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Transposon insertion sequencing of <i>Pseudomonas aeruginosa</i> identifies multiple intersecting pathways essential for extreme colistin resistanceDOI 10.64898/2026.04.13.718186
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