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Colistin resistance dynamics in Pseudomonas aeruginosa under biofilm and planktonic growth.

Antimicrobial agents and chemotherapy - 1 Oct 2025

Alarcon Rios Angie C, Zwep Laura B, Vriesendorp Bastienne, Knibbe Catherijne A J, Ciofu Oana, Liakopoulos Apostolos, Aulin Linda B S, Rozen Daniel E, van Hasselt J G Coen

Abstract excerpt

Pseudomonas aeruginosa is a major pathogen in chronic biofilm-associated lung infections, particularly in patients with cystic fibrosis. Colistin is commonly used to treat these infections, although there is little understanding of how resistance evolves when cells are grown within biofilms. The current study compared the phenotypic dynamics and genetic adaptations of colistin resistance between planktonic and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40900213
DOI: 10.1128/aac.00421-25
PMCID: PMC12486798

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