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Article

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer

12 Feb 2015

Abstract excerpt

BACKGROUND: Drug resistance is a major challenge in cancer therapeutics. Abundant evidence indicates that DNA repair systems are enhanced after repetitive chemotherapeutic treatments, rendering cancers cells drug-resistant. Flap endonuclease 1 (FEN1) plays critical roles in DNA replication and repair and in counteracting replication stress, which is a key mechanism for many chemotherapeutic drugs to kill cancer...

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PMID: 25885449
DOI: 10.1186/s12885-015-1043-1

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