Article
New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant.
DNA repair - 2 Jan 2005
Tebbs Robert S, Hinz John M, Yamada N Alice, Wilson James B, Salazar Edmund P, Thomas Cynthia B, Jones Irene M, Jones Nigel J, Thompson Larry H
Abstract excerpt
The Fanconi anemia (FA) proteins overlap with those of homologous recombination through FANCD1/BRCA2, but the biochemical functions of other FA proteins are largely unknown. By constructing and characterizing a null fancg mutant (KO40) of hamster CHO cells, we show that FancG protects cells against a broad spectrum of genotoxic agents. KO40 is consistently hypersensitive to both alkylating agents that produce...
Read the complete abstract on PubMedTopics
- Animals
- CHO Cells
- Cell Cycle
- Cricetinae
- Cricetulus
- Cross-Linking Reagents