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Article

PTEN: A potential prognostic marker in virus-induced hepatocellular carcinoma

1 Jun 2017

Abstract excerpt

PTEN is the second most frequently mutated tumor suppresser gene in cancers after p53. Genetic and epigenetic alterations in the PTEN gene and its regulatory regions have been reported in various studies. PTEN is a crucial downregulator of the pro-survival phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway and also suppresses insulin signaling. Failure to regulate these pathways leads to increase...

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Share to Hepatitis C virus research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28621226
DOI: 10.1177/1010428317705754

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