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Article

PTEN at the crossroad of metabolic diseases and cancer in the liver.

Annals of hepatology - 1 Jan 2000

Vinciguerra Manlio, Foti Michelangelo

Abstract excerpt

The tumor suppressor PTEN is a phosphoinositide phosphatase regulating the PI3K/Akt signaling pathways and mutated or deleted in a variety of human cancers. Recent evidence indicates that dysregulated PTEN expression and activity in the liver critically affect hepatic insulin sensitivity and trig...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18772845

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18772845-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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PTEN at the crossroad of metabolic diseases and cancer in the liver.PMID 18772845Read ↗

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Decoding PTEN: from biological functions to signaling pathways in tumors.Semantic proximity Read ↗

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Recent advances in PTEN signalling axes in cancerSemantic proximity Read ↗

Hepatic PTEN deficiency improves muscle insulin sensitivity and decreases adiposity in mice.Semantic proximity Read ↗

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