Article
PTEN at the crossroad of metabolic diseases and cancer in the liver.
Annals of hepatology - 1 Jan 2000
Vinciguerra Manlio, Foti Michelangelo
Abstract excerpt
The tumor suppressor PTEN is a phosphoinositide phosphatase regulating the PI3K/Akt signaling pathways and mutated or deleted in a variety of human cancers. Recent evidence indicates that dysregulated PTEN expression and activity in the liver critically affect hepatic insulin sensitivity and trigger the development of non-alcoholic fatty liver diseases. As well, PTEN expression/activity is also affected with HBV...
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