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Article

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target

9 Nov 2019

Abstract excerpt

Molecular assessment of colorectal cancer (CRC) is receiving growing attention, beyond RAS and BRAF, because of its influence on prognosis and prediction in cancer treatment. PTEN (phosphatase and tensin homologue), a tumor suppressor, regulating cell division and apoptosis, has been explored, and significant evidence suggests a role in cetuximab and panitumumab resistance linked to the epidermal growth factor...

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PMID: 31717544
DOI: 10.3390/cancers11111765

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