Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functions and Regulation of the PTEN Gene in Colorectal Cancer

1 Jan 2014

Abstract excerpt

Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor gene located at chromosome 10q23.31, encoding for a 403-amino acid protein that possesses both lipid and protein phosphatase activities. The main function of PTEN is to block the PI3K pathway by dephosphorylating phosphatidylinositol (PI) 3,4,5-triphosphate to PI-4,5-bisphosphate thus counteracting PI3K function. PTEN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colorectal Cancer Treatments and Studies
Share to PI3K/AKT/mTOR signaling in cancer
Share to Polyamine Metabolism and Applications

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24475377
DOI: 10.3389/fonc.2013.00326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functions and Regulation of the PTEN Gene in Colorectal CancerPMID 24475377Read ↗

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and TargetSemantic proximity Read ↗

The regulation of PTEN: Novel insights into functions as cancer biomarkers and therapeutic targetsSemantic proximity Read ↗

Decoding PTEN: from biological functions to signaling pathways in tumors.Semantic proximity Read ↗

PTEN as a Prognostic/Predictive Biomarker in Cancer: An Unfulfilled Promise?Semantic proximity Read ↗

A comprehensive analysis of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) loss in colorectal cancerSemantic proximity Read ↗

The functions and regulation of the PTEN tumour suppressor.Semantic proximity Read ↗

PTEN expression and mutation in colorectal carcinomas.Semantic proximity Read ↗

PTEN: Multiple Functions in Human Malignant TumorsSemantic proximity Read ↗

The PTEN–PI3K Axis in CancerSemantic proximity Read ↗

PTEN and Gynecological CancersSemantic proximity Read ↗

PTENSemantic proximity Read ↗

Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing PerspectivesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.