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Article

GOLGA7 is essential for NRAS trafficking from the Golgi to the plasma membrane but not for its palmitoylation.

Cell communication and signaling : CCS - 5 Feb 2024

Liu Chenxuan, Jiao Bo, Wang Peihong, Zhang Baoyuan, Gao Jiaming, Li Donghe, Xie Xi, Yao Yunying, Yan Lei, Qin Zhenghong, Liu Ping, Ren Ruibao

Abstract excerpt

NRAS mutations are most frequently observed in hematological malignancies and are also common in some solid tumors such as melanoma and colon cancer. Despite its pivotal role in oncogenesis, no effective therapies targeting NRAS has been developed. Targeting NRAS localization to the plasma membrane (PM) is a promising strategy for cancer therapy, as its signaling requires PM localization. However, the process...

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Identifiers

PMID: 38317235
DOI: 10.1186/s12964-024-01498-w
PMCID: PMC10845536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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