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Article

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2016

Dharmaiah Srisathiyanarayanan, Bindu Lakshman, Tran Timothy H, Gillette William K, Frank Peter H, Ghirlando Rodolfo, Nissley Dwight V, Esposito Dominic, McCormick Frank, Stephen Andrew G, Simanshu Dhirendra K

Abstract excerpt

Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are essential for its interaction with the plasma membrane where KRAS-mediated signaling events occur. Phosphodiesterase-δ (PDEδ) binds to KRAS4b and plays an important role in targeting it to cellular membranes. We solved structures of human farnesylated-methylated KRAS4b in complex with PDEδ in two different crystal forms. In these...

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Share to 3',5'-Cyclic-GMP Phosphodiesterases
Share to Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27791178
DOI: 10.1073/pnas.1615316113
PMCID: PMC5098621

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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