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Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission

29 Jun 2022

Abstract excerpt

Synucleinopathies are neurodegenerative disorders including Parkinson disease (PD), dementia with Lewy body (DLB), and multiple system atrophy (MSA) that involve deposits of the protein alpha-synuclein (α-syn) in the brain. The inoculation of α-syn aggregates derived from synucleinopathy or preformed fibrils (PFF) formed in vitro induces misfolding and deposition of endogenous α-syn. This is referred to as...

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PMID: 35768587
DOI: 10.1038/s42003-022-03590-8

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