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Article

Identifying Optimal Loci for the Molecular Diagnosis of Microsatellite Instability.

Clinical chemistry - 1 Oct 2020

Long Dustin R, Waalkes Adam, Panicker Varun P, Hause Ronald J, Salipante Stephen J

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) predicts oncological response to checkpoint blockade immunotherapies. Although microsatellite mutation is pathognomonic for the condition, loci have unequal diagnostic value for predicting MSI within and across cancer types. METHODS: To better inform molecular diagnosis of MSI, we examined 9438 tumor-normal exome pairs and 901 whole genome sequence pairs from 32...

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Identifiers

PMID: 33001187
DOI: 10.1093/clinchem/hvaa177
PMCID: PMC7528407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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