Article
Analysis of somatic microsatellite indels identifies driver events in human tumors.
Nature biotechnology - 1 Oct 2017
Maruvka Yosef E, Mouw Kent W, Karlic Rosa, Parasuraman Prasanna, Kamburov Atanas, Polak Paz, Haradhvala Nicholas J, Hess Julian M, Rheinbay Esther, Brody Yehuda, Koren Amnon, Braunstein Lior Z, D'Andrea Alan, Lawrence Michael S, Bass Adam, Bernards Andre, Michor Franziska, Getz Gad
Abstract excerpt
Microsatellites (MSs) are tracts of variable-length repeats of short DNA motifs that exhibit high rates of mutation in the form of insertions or deletions (indels) of the repeated motif. Despite their prevalence, the contribution of somatic MS indels to cancer has been largely unexplored, owing to difficulties in detecting them in short-read sequencing data. Here we present two tools: MSMuTect, for accurate...
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