Article
Microsatellite instability detection by next generation sequencing.
Clinical chemistry - 1 Sept 2014
Salipante Stephen J, Scroggins Sheena M, Hampel Heather L, Turner Emily H, Pritchard Colin C
Abstract excerpt
BACKGROUND: Microsatellite instability (MSI) is a useful phenotype in cancer diagnosis and prognosis. Nevertheless, methods to detect MSI status from next generation DNA sequencing (NGS) data are underdeveloped. METHODS: We developed an approach to detect the MSI phenotype using NGS (mSINGS). The method was used to evaluate mononucleotide microsatellite loci that were incidentally sequenced after targeted gene...
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