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Article

Classification and characterization of microsatellite instability across 18 cancer types.

Nature medicine - 1 Nov 2016

Hause Ronald J, Pritchard Colin C, Shendure Jay, Salipante Stephen J

Abstract excerpt

Microsatellite instability (MSI), the spontaneous loss or gain of nucleotides from repetitive DNA tracts, is a diagnostic phenotype for gastrointestinal, endometrial, and colorectal tumors, yet the landscape of instability events across a wider variety of cancer types remains poorly understood. To explore MSI across malignancies, we examined 5,930 cancer exomes from 18 cancer types at more than 200,000...

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Identifiers

PMID: 27694933
DOI: 10.1038/nm.4191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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