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Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growth

12 Jun 2017

Abstract excerpt

Breast tumours progress from hyperplasia to ductal carcinoma in situ (DCIS) and invasive breast carcinoma (IBC). PRH/HHEX (proline-rich homeodomain/haematopoietically expressed homeobox) is a transcription factor that displays both tumour suppressor and oncogenic activity in different disease contexts; however, the role of PRH in breast cancer is poorly understood. Here we show that nuclear localization of the...

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PMID: 28604763
DOI: 10.1038/oncsis.2017.42

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