Article
PRH represses transcription in hematopoietic cells by at least two independent mechanisms.
The Journal of biological chemistry - 26 Jan 2001
Guiral M, Bess K, Goodwin G, Jayaraman P S
Abstract excerpt
PRH (proline-rich homeodomain protein) is strongly expressed in the hematopoietic compartment. Here we show that PRH is a repressor of transcription in hematopoietic cells. A fragment of PRH that includes the homeodomain can bind to TATA box sequences in vitro and can also bind to the TATA box-binding protein. PRH represses transcription from TATA box-containing promoters in intact cells but does not repress...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.