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Article

A Runaway PRH/HHEX-Notch3-Positive Feedback Loop Drives Cholangiocarcinoma and Determines Response to CDK4/6 Inhibition.

Cancer research - 15 Feb 2020

Kitchen Philip, Lee Ka Ying, Clark Danielle, Lau Nikki, Lertsuwan Jomnarong, Sawasdichai Anyaporn, Satayavivad Jutamaad, Oltean Sebastian, Afford Simon, Gaston Kevin, Jayaraman Padma-Sheela

Abstract excerpt

Aberrant Notch and Wnt signaling are known drivers of cholangiocarcinoma (CCA), but the underlying factors that initiate and maintain these pathways are not known. Here, we show that the proline-rich homeodomain protein/hematopoietically expressed homeobox (PRH/HHEX) transcription factor forms a positive transcriptional feedback loop with Notch3 that is critical in CCA. PRH/HHEX expression is elevated in CCA, and...

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Identifiers

PMID: 31843982
DOI: 10.1158/0008-5472.CAN-19-0942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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