Article

Prolylcarboxypeptidase Promotes IGF1R/HER3 Signaling and Is a Potential Target to Improve Endocrine Therapy Response in Estrogen Receptor Positive Breast Cancer

2021-12-10

Abstract excerpt

<h4>Background: </h4> Prolylcarboxypeptidase (PRCP) is a lysosomal serine protease that cleaves peptide substrates when the penultimate amino acid is proline. Previous studies have linked PRCP to blood-pressure and appetite control through its ability to cleave peptide substrates such as angiotensin II and a-MSH. A potential role for PRCP in cancer has to date not been widely appreciated. Endocrine therapy resista...

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Literature Corpus work: 62d78efc-9f6c-5f89-b85b-9a9e6b8762f1
DOI: 10.21203/rs.3.rs-1153270/v1

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