Article
CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding.
Nucleic acids research - 1 Jun 2009
Soufi Abdenour, Noy Peter, Buckle Malcolm, Sawasdichai Anyaporn, Gaston Kevin, Jayaraman Padma-Sheela
Abstract excerpt
The proline-rich homeodomain protein (PRH/Hex) regulates transcription by binding to specific DNA sequences and regulates mRNA transport by binding to translation initiation factor eIF4E. Protein kinase CK2 plays multiple roles in the regulation of gene expression and cell proliferation. Here, we show that PRH interacts with the beta subunit of CK2 in vitro and in cells and that CK2 phosphorylates PRH....
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