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Article

BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer.

Breast cancer research and treatment - 1 Aug 2010

Gorski Julia J, James Colin R, Quinn Jennifer E, Stewart Gail E, Staunton Kieran Crosbie, Buckley Niamh E, McDyer Fionnuala A, Kennedy Richard D, Wilson Richard H, Mullan Paul B, Harkin D Paul

Abstract excerpt

Expression profiling of BRCA1-deficient tumours has identified a pattern of gene expression similar to basal-like breast tumours. In this study, we examine whether a BRCA1-dependent transcriptional mechanism may underpin the link between BRCA1 and basal-like phenotype. In methods section, the mRNA and protein were harvested from a number of BRCA1 mutant and wild-type breast cancer cell lines and from matched...

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Source

Identifiers

PMID: 19882246
DOI: 10.1007/s10549-009-0565-0

Genes

BRCA1
CDH3
KRT17
KRT5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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