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Article

The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors.

The Biochemical journal - 1 Jan 2009

Desjobert Cecile, Noy Peter, Swingler Tracey, Williams Hannah, Gaston Kevin, Jayaraman Padma-Sheela

Abstract excerpt

The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a transcription factor that functions as an important regulator of vertebrate development and many other processes in the adult including haematopoiesis. The Groucho/TLE (transducin-like enhancer) family of co-repressor proteins also regulate development and modulate the activity of many DNA-binding...

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Identifiers

PMID: 18713067
DOI: 10.1042/BJ20080872
PMCID: PMC2605961

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The PRH/Hex repressor protein causes nuclear retention of Groucho/TLE co-repressors.PMID 18713067Read ↗

PRH represses transcription in hematopoietic cells by at least two independent mechanisms.Semantic proximity Read ↗

Aristaless-related homeobox gene, the gene responsible for West syndrome and related disorders, is a Groucho/transducin-like enhancer of split dependent transcriptional repressor.Semantic proximity Read ↗

Regulation of gene expression by repression condensates during developmentSemantic proximity Read ↗

Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis.Semantic proximity Read ↗

Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.Semantic proximity Read ↗

Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Semantic proximity Read ↗

Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development.Semantic proximity Read ↗

Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho.Semantic proximity Read ↗

The Trithorax-mimic allele of Enhancer of zeste renders active domains of target genes accessible to polycomb-group-dependent silencing in Drosophila melanogaster.Semantic proximity Read ↗

Hesx1 homeodomain protein represses transcription as a monomer and antagonises transactivation of specific sites as a homodimer.Semantic proximity Read ↗

Proline-Rich Homeodomain protein (PRH/HHEX) is a suppressor of breast tumour growthSemantic proximity Read ↗

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