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Article

Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression.

Cancer research - 1 Jul 2007

Privette Lisa M, González Maria E, Ding Lei, Kleer Celina G, Petty Elizabeth M

Abstract excerpt

Checkpoint with FHA and Ring Finger (CHFR) is hypothesized to mediate a delay in cell cycle progression early in mitosis in response to microtubule stress, independent of the spindle assembly checkpoint. As a potential regulator of cell cycle progression, CHFR naturally becomes an interesting target for understanding cancer cells. In recent years, there has been increasing evidence supporting the role of CHFR as...

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Source

Identifiers

PMID: 17596595
DOI: 10.1158/0008-5472.CAN-06-4109

Genes

CHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression.PMID 17596595Read ↗

CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and DegradationSemantic proximity Read ↗

Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer.Semantic proximity Read ↗

Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice.Semantic proximity Read ↗

Epigenetic inactivation of the CHFR gene in cervical cancer contributes to sensitivity to taxanesSemantic proximity Read ↗

CHFR gene variations: A novel cause for hereditary cancer predisposition?Semantic proximity Read ↗

FOXM1 is critical for the fitness recovery of chromosomally unstable cellsSemantic proximity Read ↗

CHFR hypermethylation, a frequent event in acute myeloid leukemia, is independently associated with an adverse outcome.Semantic proximity Read ↗

Coding region polymorphisms in the CHFR mitotic stress checkpoint gene are associated with colorectal cancer risk.Semantic proximity Read ↗

FAM190A deficiency creates a cell division defect.Semantic proximity Read ↗

CHFR gene is neither mutated nor hypermethylated in ovarian cancer.Semantic proximity Read ↗

Overexpression of the E2F target gene CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancerSemantic proximity Read ↗

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.Semantic proximity Read ↗

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