Article
Deletion of the proline-rich region of the murine metastasis susceptibility gene Brd4 promotes epithelial-to-mesenchymal transition- and stem cell-like conversion.
Cancer research - 15 Apr 2011
Alsarraj Jude, Walker Renard C, Webster Joshua D, Geiger Thomas R, Crawford Nigel P S, Simpson R Mark, Ozato Keiko, Hunter Kent W
Abstract excerpt
The bromodomain-containing chromatin-modifying factor BRD4 is an inherited susceptibility gene for breast cancer progression and metastasis, but its functionality in these settings has yet to be explored. Here we show that deletion of either of the BRD4 bromodomains had modest effects on the metastatic suppression ability of BRD4. In contrast, expression of the natural short isoform of BRD4 that truncates the...
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