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Article

Chromosome instability and kinetochore dysfunction.

Histology and histopathology - 1 Feb 2007

Tomonaga T, Nomura F

Abstract excerpt

Chromosomal instability (CIN) has been recognized as a hallmark of human cancer and is caused by continuous chromosome missegregation during mitosis. Proper chromosome segregation requires a physical connection between spindle microtubules and centromeric DNA and this attachment occurs at protein...

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PMID: 17149692
DOI: 10.14670/HH-22.191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17149692-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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