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Article

Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis.

American journal of physiology. Gastrointestinal and liver physiology - 15 Nov 2014

Terry Natalie A, Walp Erik R, Lee Randall A, Kaestner Klaus H, May Catherine Lee

Abstract excerpt

Enteroendocrine cells secrete over a dozen different hormones responsible for coordinating digestion, absorption, metabolism, and gut motility. Loss of enteroendocrine cells is a known cause of severe congenital diarrhea. Furthermore, enteroendocrine cells regulate glucose metabolism, with the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) playing critical...

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Source

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Identifiers

PMID: 25214396
DOI: 10.1152/ajpgi.00390.2013
PMCID: PMC4233286

Genes

GIP
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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