Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An <i>in vivo</i> analysis in MIRKO mice

Abstract excerpt

Diabetes mellitus is a complex metabolic disorder accompanied by alterations in cellular physiology, metabolism, and gene expression. These alterations can be primary (due to loss of direct insulin action) or secondary (due to the metabolic perturbations associated with the disease). To dissect and quantitate these two separate effects, we compared the skeletal muscle gene-expression profiles of muscle insulin...

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