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Article

Characterization of an intelectin-1 (Itln1) knockout mouse model

22 Aug 2022

Abstract excerpt

Intelectins are carbohydrate-binding proteins implicated in innate immunity and highly conserved across chordate evolution, including both ascidians and humans. Human intelectin-1 (ITLN1) is highly abundant within the intestinal mucosa and binds microbial but not host glycans. Genome-wide association studies identified SNPs in ITLN1 that are linked to susceptibility for Crohn’s disease. Moreover, ITLN1 has been...

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PMID: 36072603
DOI: 10.3389/fimmu.2022.894649

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