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Article

Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stress-mediated intestinal mucosal injury and inflammation in zebrafish.

Disease models & mechanisms - 1 Jan 2014

Thakur Prakash C, Davison Jon M, Stuckenholz Carsten, Lu Lili, Bahary Nathan

Abstract excerpt

Dysregulated phosphatidylinositol (PI) signaling has been implicated in human gastrointestinal (GI) malignancies and inflammatory states, underlining the need to study pathophysiological roles of PI in an in vivo genetic model. Here, we study the significance of PI in GI pathophysiology using the zebrafish mutant cdipt(hi559), which lacks PI synthesis, and unravel a crucial role of PI in intestinal mucosal...

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Source

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Identifiers

PMID: 24135483
DOI: 10.1242/dmm.012864
PMCID: PMC3882052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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