Article
Proteomic Analysis of the Intestinal Resistance to Thyroid Hormone Mouse Model With Thyroid Hormone Receptor Alpha Mutations.
Frontiers in endocrinology - 1 Jan 2022
Xi Yue, Zhang Dan, Liang Yue, Shan Zhongyan, Teng Xiaochun, Teng Weiping
Abstract excerpt
Thyroid hormone is critical during the development of vertebrates and affects the function of many organs and tissues, especially the intestine. Triiodothyronine (T3) is the active form and can bind to thyroid hormone nuclear receptors (TRs) to play a vital role in the development of vertebrates. The resistance to thyroid hormone α, as seen in patients, has been mimicked by the ThraE403X mutation. To investigate...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.