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Article

Insulin receptor isoform switching in intestinal stem cells, progenitors, differentiated lineages and tumors: evidence that IR-B limits proliferation.

Journal of cell science - 15 Dec 2013

Andres Sarah F, Simmons James G, Mah Amanda T, Santoro M Agostina, Van Landeghem Laurianne, Lund P Kay

Abstract excerpt

Despite evidence for the impact of insulin on intestinal epithelial physiology and pathophysiology, the expression patterns, roles, and regulation of insulin receptor (IR) and IR isoforms in the intestinal epithelium are not well characterized. IR-A is thought to mediate the proliferative effects of insulin or insulin growth factors (IGFs) in fetal or cancer cells. IR-B is considered to be the metabolic receptor...

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Identifiers

PMID: 24127567
DOI: 10.1242/jcs.132985
PMCID: PMC3860310

Genes

MBNL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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