Article
Genome-wide analysis identifies colonic genes differentially associated with serum leptin and insulin concentrations in C57BL/6J mice fed a high-fat diet.
PloS one - 1 Jan 2017
Kim Sung-Eun, Choo Jinsil, Yoon Joon, Chu Jae Ryang, Bae Yun Jung, Lee Seungyeoun, Park Taesung, Sung Mi-Kyung
Abstract excerpt
Obesity-induced chronic inflammation is known to increase the risk of ulcerative colitis, Crohn's disease, and colorectal cancer. Accumulating evidence suggests that leptin and insulin are key molecules linking obesity with diseases of the lower intestine. Here, we identified serum phenotype-associated genes in the colon of diet-induced obese mice as early biomarkers of obesity-associated colonic diseases....
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