Article
BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations.
Oncotarget - 20 Jun 2017
Deihimi Safoora, Lev Avital, Slifker Michael, Shagisultanova Elena, Xu Qifang, Jung Kyungsuk, Vijayvergia Namrata, Ross Eric A, Xiu Joanne, Swensen Jeffrey, Gatalica Zoran, Andrake Mark, Dunbrack Roland L, El-Deiry Wafik S
Abstract excerpt
Deficient mismatch repair (MMR) and microsatellite instability (MSI) contribute to ~15% of colorectal cancer (CRCs). We hypothesized MSI leads to mutations in DNA repair proteins including BRCA2 and cancer drivers including EGFR. We analyzed mutations among a discovery cohort of 26 MSI-High (MSI-H) and 558 non-MSI-H CRCs profiled at Caris Life Sciences. Caris-profiled MSI-H CRCs had high mutation rates (50% vs...
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