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Article

Next-generation sequencing reveals heterogeneous genetic alterations in key signaling pathways of mismatch repair deficient colorectal carcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2020

Wang Jing, Li Ruiyu, He Yangzhige, Yi Yuting, Wu Huanwen, Liang Zhiyong

Abstract excerpt

Colorectal carcinoma (CRC) with deficient mismatch repair (dMMR) is an etiologically heterogeneous molecular entity. We investigated the genetic profile, focusing on key signaling pathways and molecular diversity of dMMR CRCs. In this study, next-generation sequencing was applied to 156 consecutive dMMR CRCs and 225 randomly selected proficient MMR (pMMR) CRCs diagnosed between July 2015 and December 2019 at...

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Identifiers

PMID: 32620917
DOI: 10.1038/s41379-020-0612-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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