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Article

Microsatellite instability in mismatch repair proficient colorectal cancer: clinical features and underlying molecular mechanisms.

EBioMedicine - 1 May 2024

Xu Yun, Liu Kai, Li Cong, Li Minghan, Zhou Xiaoyan, Sun Menghong, Zhang Liying, Wang Sheng, Liu Fangqi, Xu Ye

Abstract excerpt

BACKGROUND: Both defects in mismatch repair (dMMR) and high microsatellite instability (MSI-H) have been recognised as crucial biomarkers that guide treatment strategies and disease management in colorectal cancer (CRC). As MMR and MSI tests are being widely conducted, an increasing number of MSI-H tumours have been identified in CRCs with mismatch repair proficiency (pMMR). The objective of this study was to...

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Source

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Identifiers

PMID: 38691939
DOI: 10.1016/j.ebiom.2024.105142
PMCID: PMC11070601

Genes

MSH3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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