Article

Mutational signature profiling classifies subtypes of clinically different mismatch repair deficient tumors with a differential immunogenic response potential

2021-09-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mismatch repair (MMR) deficiency is the hallmark of tumors from Lynch syndrome (LS), sporadic MLH1 hypermethylated, and Lynch-like syndrome (LLS), but there is a lack of understanding of the variability in their mutational profiles based on clinical phenotypes. The aim of this study was to perform a molecular characterization to identify novel features that can impact tumor...

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Literature Corpus work: e6dc5aa1-6997-593f-8465-fddc9ab8bbb7
DOI: 10.1101/2021.09.28.460630

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