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Article

Prevalence and Associations of Beta2-Microglobulin Mutations in MSI-H/dMMR Cancers.

The oncologist - 17 Mar 2023

Liu Fangcen, Zhong Fangfang, Wu Huan, Che Keying, Shi Jiaochun, Wu Nandie, Fu Yao, Wang Yue, Hu Jing, Qian Xiaoping, Fan Xiangshan, Wang Weifeng, Wei Jia

Abstract excerpt

Microsatellite instability (MSI) has emerged as an important predictor of sensitivity for immunotherapy-based strategies. β-2-Microglobulin (B2M) contains microsatellites within the coding regions and is prone to somatic changes in MSI/mismatch repair deficiency (MSI/dMMR) tumors. To delineate prevalence and associations of B2M mutations in MSI-H/dMMR cancers, we investigated the mutational profile of B2M and...

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Identifiers

PMID: 36724040
DOI: 10.1093/oncolo/oyac268
PMCID: PMC10020813

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